Template:Amanda & Elisa - Port Melissa University faculty

• Principal Carla Mughmaw (voiced by Ava Zinn) : the principal of Port Melissa Univeristy. Mughmaw suffers from extreme nervous tension caused by having to deal with Amanda and Elisa over the years. She is the character who hates the duo more than anyone else. She speaks with a Texas accent, constantly shakes, her voice is strained, and she keeps a bottle of vodka in her desk, from which she drinks even when people are present. Mughmaw also has a bottle of pills (presumably anti-depressants) that she keeps in her desk and also will use (by the handful) in public. She also has threatened to kill Amanda and Elisa. Most commonly, she also refers to the duo as "little bitches"; in return, the duo refers to Mughmaw as "Dumbaw". When Amanda and Elisa are expelled in the last episode, Mughmaw organizes a teachers' party. When they show up at though, Mughmaw suffers a heart attack, and Coach Shorthair attempts to resuscitate her afterwards with CPR, while Amanda and Elisa incorrectly assume she was "making out" with Mughmaw. Mughmaw has a daughter, Nancy, who appears in the Queen of the Willis episode "The Rape of Heather Willis".

• Coach Debbie Shorthair (voiced by Holly Everman): is in charge of Physical Education, Math and Science; the angry, loud-mouthed, antisocial Shorthair dislikes Amanda and Elisa nearly as much as Principal Mughtmaw does. She has a military background in the United States Army. She takes great pleasure in belittling anyone, especially the duo. She looks at them as personifying everything wrong with humanity.

• Dana Carson (née Driessen) (voiced by Ava Zinn): A teacher who is characterized as an extremely liberal educator. Specifically, she is a pacifist, concerned about environmental protection, believes in aid for foreign countries, and women's rights. She generally speaks in a soft, gentle voice, encourages her students to get in touch with their feelings, and often plays folk songs on her keyboard. She has a habit of ending nearly every sentence with "M'kay?" Carson has had many near-death experiences during the course of the show (often, as a direct result of Amanda and Elisa's actions). Most of the teachers at Port Melissa Univeristy despise Amanda and Elisa, but Carson sympathizes with them and believes them to be somehow capable of salvation except in Cleaning House where she finally lost her patience by wanting to kill the duo after they wrecked her cassette tape collection. Her attempts to appeal to their better sides, however, invariably fail. In the series finale "Amanda and Elisa's Judgement Day", in which the girls are mistakenly assumed to be deceased, Carson is the only teacher who expresses sadness, going as far as to cry and express disbelief when the announcement is made. All her colleagues celebrate with a party. In Queen of the Willis, Ava Willis is said to have attended Port Melissa Univeristy and Carson was her professor.