Template:Pamhouser - Family and Romantic life

Pamhouser has four relatives that have appeared on the show: her "Pahpaw" (a Southern term for grandfather); her father, Mr. Pamhouser; her mother, Dr. Pamhouser; and her sleazy, chauvinistic sister, Paige, voiced by Angelina Jole in her only speaking appearance (she appeared again for a split second at Deanna and Brandi's wedding). They live in California. Mr. Pamhouser, Paige, and Pahpaw all have the same speaking pattern as Pamhouser. Dr. Pamhouser has not been shown speaking, only through other characters paraphrasing what she may have said. She is the aunt of Paige's daughter, Pauline Pamhouser.

Pamhouser's typical romantic life includes one-night stands with several young men. Angie Willis once mentions (likely in jest) her longest relationship was a three-day weekend. Occasionally, she had boyfriends that she dated for more than sex. When a man breaks up with her, she is notably devastated. In the episode "Uh-Oh, MEXICO!", Pamhouser moves to Tijuana, Baja California, Mexico and has a 3-month relationship with a Spanish-Mexican American man.